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Heat shock activation of NFkB in rat liver is mediated by interleukin‐1
Author(s) -
Pogliaghi Giovanna,
Tacchini Lorenza,
Anzon Elena,
Radice Laura,
Bernelli-Zazzera Aldo
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00973-d
Subject(s) - interleukin 1β , chemistry , shock (circulatory) , interleukin , heat shock protein , medicine , biochemistry , cytokine , gene
Exposure to high temperature (heat shock) activates the transcription factor NFkB in the liver of the living rat, but is not effective in hepatoblastoma cells in culture: on the contrary, activation of the heat shock transcription factor (HSF) occurs under both conditions. Pre‐treatment of the rat with IL‐1 receptor antagonist suppresses the activation of NFkB, which seems to be mediated by the release of this cytokine, but does not hamper the activation of HSF and the concurrent induction of hsp 70 mRNA. IL‐1 activity actually shows a strong, albeit transient, increase in the blood of heat shocked rats.