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Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin‐1: a potential mechanism for inflammatory angiogenesis
Author(s) -
Ben-Av Pazit,
Crofford Leslie J.,
Wilder Ronald L.,
Hla Timothy
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00956-a
Subject(s) - angiogenesis , vascular endothelial growth factor , vascular endothelial growth factor a , protein kinase a , chemistry , microbiology and biotechnology , cancer research , prostaglandin e , endocrinology , medicine , kinase , biology , vegf receptors
Inflammatory mediators such as prostaglandin E 2 (PGE 2 ) and interleukin‐1 (IL‐1) induce angiogenesis by yet undefined mechanisms. We demonstrate that PGE 2 and IL‐1 induces the expression of vascular endothelial growth factor (VEGF), a selective angiogenic factor by rheumatoid synovial fibroblast cells. Transcripts for the EP 1 and EP 2 , subtypes of PGE receptors are expressed in synovial fibroblasts. Activators of protein kinase A pathway stimulated the expression of VEGF whereas down‐regulation of protein kinase C did not influence the PGE effect, suggesting that signalling from the EP 2 receptor via the protein kinase A pathway is important. The induction of VEGF expression by PGE 2 and interleukin‐1α a may be an important mechanism in inflammatory angiogenesis.