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The death domain motif found in Fas (Apo‐1) and TNF receptor is present in proteins involved in apoptosis and axonal guidance
Author(s) -
Kay Hofmann,
J Tschopp
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00931-x
Subject(s) - death domain , apoptosis , fas receptor , microbiology and biotechnology , receptor , signal transduction , programmed cell death , cytoplasm , biology , chemistry , genetics
The interaction of Fas (Apo‐1) and TNF receptor‐1 with their respective ligands can lead to cell death. The so‐called death domain, a sequence motif present in the cytoplasmic portion of the two receptors, has been identified as a critical structural element involved in signal transduction that leads to apoptosis. Here we describe several additional proteins which contain a death domain. Novel members of this family include proteins known to be implicated not only in apoptosis but also in neuron guidance.