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The major acute phase serum protein in pigs is homologous to human plasma kallikrein sensitive PK‐120
Author(s) -
Nieves GonzálezRamón,
Alava Ma,
Sarsa Ja,
Matilde Piñeiro,
Alfredo Escartín,
Alejandro GarcíaGil,
Fermı́n Lampreave,
Andrés Piñeiro
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00882-a
Subject(s) - kallikrein , trypsin , homology (biology) , microbiology and biotechnology , chemistry , homologous chromosome , acute phase protein , biochemistry , biology , amino acid , enzyme , gene , immunology , inflammation
A major acute phase protein (pig‐MAP) has been isolated from the sera of pigs after turpentine injection. The protein is the pig counterpart of a recently cloned human serum protein denominated PK‐120, which is a putative substrate for kallikrein [Nishimura et al., 1995 FEBS Lett. 357, 207–211]. The protein exists in other mammalian species and it is also an acute phase protein, at least in the rat. Pig‐MAP shows homology, as PK‐120, with the heavy chain 2 (HC‐2) of the inter‐α‐trypsin inhibitor superfamily but does not possess trypsin inhibitory activity.