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The Drosophila learning and memory gene linotte encodes a putative receptor tyrosine kinase homologous to the human RYK gene product
Author(s) -
Dura Jean-Maurice,
Taillebourg Emmanuel,
Préat Thomas
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00847-3
Subject(s) - receptor tyrosine kinase , biology , tyrosine kinase , gene product , ror1 , mutant , receptor protein tyrosine kinases , mapk7 , microbiology and biotechnology , gene , signal transduction , biochemistry , receptor , genetics , gene expression , map kinase kinase kinase , mapk/erk pathway , platelet derived growth factor receptor , growth factor
The linotte mutant was isolated on the basis of its learning and memory deficit. Interestingly, linotte individuals carrying a null mutation are viable, indicating that the linotte gene is not required for vital functions. We show here that the linotte gene encodes a putative receptor tyrosine kinase, homologous to the human protein RYK. These products are unique among receptor tyrosine kinases, since they possess a short extra cellular domain, and a modified intracellular catalytic domain. In particular, the subdomains directly involved in ATP binding and phosphotransfer reaction display remarkable variations. These results suggest that linotte is part of a novel signal transduction cascade involved in learning and memory.