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Action of nitric oxide as an antioxidant against oxidation of soybean phosphatidylcholine liposomal membranes
Author(s) -
Hayashi Katsunobu,
Noguchi Noriko,
Niki Etsuo
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00786-9
Subject(s) - phosphatidylcholine , liposome , nitric oxide , chemistry , antioxidant , membrane , biochemistry , phospholipid , organic chemistry
To elucidate the protective role of nitric oxide (NO) against lipid peroxidation, the effect of NO donor on the formation of lipid hydroperoxide and consumption of α‐tocopherol in the oxidation of soybean phosphatidylcholine liposomal membranes was studied. The oxidation was induced by either aqueous or lipophilic peroxyl radicals generated by the hydrophilic or lipophilic azo compound, respectively. It was found that NO acted as a potent antioxidant by scavenging peroxyl radicals rapidly. It was also found that NO was capable of penetrating multilamellar membranes to scavenge lipid peroxyl radicals and spare α‐tocopherol.