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Alternative splicing of the human Shaker K + channel β1 gene and functional expression of the β2 gene product
Author(s) -
McCormack Ken,
McCormack Tom,
Tanouye Mark,
Rudy Bernardo,
Stühmer Walter
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00785-8
Subject(s) - shaker , alternative splicing , gene , gene product , gene expression , biology , rna splicing , microbiology and biotechnology , biochemistry , chemistry , exon , rna , physics , quantum mechanics , vibration
Mammalian voltage‐activated Shaker K + channels associate with at least three cytoplasmic proteins: Kvβ1, Kvβ2 and Kvβ3. These β subnunits contain variable N‐termini, which can modulate the inactivation of Shaker α subunits, but are homologous throughout an aldo‐keto reductase core. Human and ferret β3 proteins are identical with rat β1 throughout the core while β2 proteins are not; β2 also contains a shorter N‐terminus and has no reported physiological role. We report that human β1 and β3 are derived from the same gene and that β2 modulates the inactivation properties of Kv1.4 α subunits.