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Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase
Author(s) -
Brown Guy C.
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00763-y
Subject(s) - cytochrome c oxidase , respiration , mitochondrion , cytochrome , nitric oxide , oxidase test , alternative oxidase , cytochrome c , biochemistry , cellular respiration , oxygen , chemistry , electron transport complex iv , microbiology and biotechnology , biology , biophysics , enzyme , anatomy , organic chemistry
Nitric oxide (NO) reversibly inhibits mitochondrial respiration by competing with oxygen at cytochrome oxidase. Concentrations of NO measured in a range of biological systems are similar to those shown to inhibit cytochrome oxidase and mitochondrial respiration. Inhibition of NO synthesis results in a stimulation of respiration in a number of systems. It is proposed that NO exerts some of its main physiological and pathological effects on cell functions by inhibiting cytochrome oxidase. Further NO may be a physiological regulator of the affinity of mitochondrial respiration for oxygen, enabling mitochondria to act as sensors of oxygen over the physiological range.