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Influence of synthetic peptides, corresponding to fragments of the human α‐2 interferon molecule, on the proliferation of lymphoblastoid cells in vitro. Growth inhibition and receptor binding
Author(s) -
Danilkovich A.,
Freze K.,
Romashkova J.,
Valujskikh A.,
Makarov E.,
Targoni O.,
Makarova N.,
Kushch A.
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00731-n
Subject(s) - lymphoblast , receptor , in vitro , cell surface receptor , peptide , microbiology and biotechnology , cell culture , binding site , chemistry , cell growth , cell membrane , biology , membrane , biochemistry , genetics
Influence of nine synthetic peptides from the C‐terminal part of human α‐2 interferon (EN) molecule on growth of a human T‐lymphoblastoid cell line MT‐4 was investigated. It was shown that some peptides inhibited the proliferation of MT‐4 cells. It was also found that MT‐4 cells expressed specific receptors on the outer surface of the plasma membrane. All studied peptides competed for binding to a common binding site. Antiproliferative activity of the peptides correlated with their length and affinity to receptors on the outer membrane of MT‐4 cells.