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Lipopolysaccharide treatment in vivo induces tissue expression of GTP cyclohydrolase I mRNA
Author(s) -
Hattori Yoshiyuki,
Oka Muneo,
Kasai Kikuo,
Nakanishi Nobuo,
Shimoda Shin-Ichi
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00689-7
Subject(s) - gtp cyclohydrolase i , in vivo , messenger rna , lipopolysaccharide , tetrahydrobiopterin , nitric oxide , nitric oxide synthase , kidney , medicine , endocrinology , gtp' , chemistry , biology , biochemistry , enzyme , gene , microbiology and biotechnology
A significant induction of GTP cyclohydrolase I (GTPCH) mRNA was observed in lung, heart and kidney of rats treated with lipopolysaccharide (LPS; 10 mg/kg i.v.). GTPCH mRNA levels in liver were high even in untreated rats, and remained elevated after LPS treatment. Parallel induction of nitric oxide synthase (NOS) mRNA was observed in these tissues of LPS‐treated rats. Our results demonstrate induction of GTPCH mRNA after LPS treatment in vivo and provide molecular evidence for the increased GTPCH activity which may up‐regulate NOS activity in vivo.