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Effects of delta‐sleep inducing peptide (DSIP) and some analogues on the activity of monoamine oxidase type A in rat brain under hypoxia stress
Author(s) -
Khvatova Elena M.,
Rubanova Natalia A.,
Prudchenko Igor A.,
Mikhaleva Inessa I.
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00661-r
Subject(s) - monoamine oxidase , serotonin , endocrinology , hypoxia (environmental) , medicine , monoamine neurotransmitter , neuropeptide y receptor , chemistry , neuropeptide , peptide , monoamine oxidase a , biology , biochemistry , oxygen , enzyme , receptor , organic chemistry
Metabolic effects of delta‐sleep inducing peptide (DSIP) under hypoxia stress were investigated in rats subjected to short‐term hypoxic conditions (about 0.26 Bar). It was found that DSIP partially restricted stress‐induced changes in activity of mitochondrial monoamine oxidase type A (MAO‐A) and serotonin level in rat brain. A number of DSIP analogues was tested and among them there were some compounds with enhanced ability to counteract hypoxia induced changes in MAO‐A activity and serotonin content in comparison with native neuropeptide.