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Epidermal growth factor inhibits cytokine‐dependent nitric oxide synthase expression in hepatocytes
Author(s) -
Terenzi Fulvia,
Casado Marta,
Martin-Sanz Paloma,
Boscá Lisardo
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00646-q
Subject(s) - nitric oxide synthase , epidermal growth factor , cytokine , nitric oxide , microbiology and biotechnology , extracellular , lipopolysaccharide , incubation , chemistry , receptor , growth factor , tumor necrosis factor alpha , biology , biochemistry , endocrinology , immunology
Liver cells express a wide range of extracellular receptors involved in the control of cell growth and arrest that can be studied ex vivo. Incubation of primary cultures of hepatocytes with IL‐1β, TNF‐α or lipopolysaccharide promotes the expression of the inducible form of nitric oxide synthase and NO release, a process that is inhibited to a different extent by incubation of the cells with EGF. In addition to this growth factor, IL‐6 and TGF‐β also inhibited NO synthesis. Therefore, EGF by itself or in combination with other cytokines may be involved in the downregulation of the NO synthesis that occurs in the early steps of liver regeneration.