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Antioxidant potential of intermediates in phenylpropanoid metabolism in higher plants
Author(s) -
Castelluccio Cinzia,
Paganga George,
Melikian Narbeh,
Paul Bolwell G.,
Pridham John,
Sampson Julia,
Rice-Evans Catherine
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00639-q
Subject(s) - chemistry , caffeic acid , antioxidant , ferulic acid , phenylpropanoid , lipid peroxidation , biochemistry , metmyoglobin , dpph , coumaric acid , oxidative phosphorylation , myoglobin , enzyme , biosynthesis
In this study the antioxidant activities of the hydroxycinnamic acids, chlorogenic, caffeic, ferulic and p ‐coumaric have been investigated in peroxidising lipid systems mediated by metmyoglobin. The results show that the order of effectiveness in increasing the resistance of LDL to peroxidation, in protecting LDL cholesterol from oxidation and preventing the oxidative modification of the LDL apoprotein B 100 is caffeic = chlorogenic > ferulic > p ‐coumaric acid. Assessment of the rates of reaction of the hydroxycinnamates with ferrylmyoglobin, a product of the reductive decomposition of lipid hydroperoxides, reveals that the compounds are more effective as peroxyl radical scavengers than reductants of ferryl myoglobin in peroxidising LDL systems mediated by haem proteins.