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Intracellular lipid heterogeneity caused by topology of synthesis and specificity in transport. Example: sphingolipids
Author(s) -
van Helvoort Ardy,
van Meer Gerrit
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00616-h
Subject(s) - sphingolipid , golgi apparatus , organelle , microbiology and biotechnology , intracellular , vesicle , membrane , vesicular transport protein , biology , biochemistry , cell , chemistry , biophysics
The differences in lipid composition between intracellular membranes cannot be adequately explained by local synthesis and degradation. Especially in the case of sphingolipids, which are synthesized in the Golgi complex but enriched on the cell surface and in endocytotic organelles, there is evidence for a cellular machinery that preferentially shuttles these lipids in vesicles to the cell surface. The machinery appears to involve the formation of domains of sphingolipid and cholesterol in the lumenal leaflet of Golgi membranes. Several pieces of evidence suggest that the selective anterograde transport of plasma membrane proteins may be mechanistically related to the sphingolipid domains.