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PTF1 encodes an essential protein in Saccharomyces cerevisiae , which shows strong homology with a new putative family of PPIases
Author(s) -
Hani J.,
Stumpf G.,
Domdey H.
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00471-k
Subject(s) - saccharomyces cerevisiae , complementation , homology (biology) , genetics , biology , mutant , gene , transcription factor , protein family , yeast
Complementation of a temperature sensitive mutant of the yeast Saccharomyces cerevisiae resulted in the isolation of PTF1 (processing/termination factor 1), an essential gene encoding a putative 3′‐end processing or transcription termination factor of pre‐mRNAs. Ptf1p shows significant homology to a newly discovered family of PPIases. This family is characterized by its insensitivity to immunosuppressive drugs and the lack of homology with cyclophilins and FK‐506 binding proteins [Rahfeld et al. (1994) FEBS Lett. 352, 180–184]. Should Ptf1p display PPIase activity, it would be the first characterized, eukaryotic member of this putative family, which is essential for growth.