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Genomic structure of the mouse A‐type lamin gene locus encoding somatic and germ cell‐specific lamins
Author(s) -
Nakajima Noboru,
Abe Kenji
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00453-g
Subject(s) - lamin , biology , gene , somatic cell , locus (genetics) , genetics , exon , promoter , intron , microbiology and biotechnology , gene expression
Mouse A‐type lamin genes were isolated. Structural analyses revealed that all the three known mouse A‐type lamins (A, C and C2) were coded in a single genomic locus in a 22 kilobase DNA segment. The three lamins were coded in 12, 10 and 10 exons for A, C and C2, respectively, and shared 8 exons among them. Primer extension analyses identified possible transcription start sites for both A/C and C2 genes suggesting that the locus is under the control of two separate promoters, that is a somatic cell‐acting promoter (for A and C) and a testis‐specific promoter (for C2) which resides in the first intron of the A/C gene. Sequence characteristics of the possible promoter regions are discussed. Divergence of the two somatic cell‐type lamins (A and C) is formally accounted for by differential selection of poly(A) sites together with lamin A‐specific splicing.