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Amylin and epinephrine have no direct effect on glucose transport in isolated rat soleus muscle
Author(s) -
Pittner Richard A.,
Wolfe-Lopez Deborah,
Young Andrew A.,
Rink Timothy J.
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00449-j
Subject(s) - glycogenolysis , amylin , epinephrine , medicine , soleus muscle , endocrinology , glucose transporter , insulin , chemistry , skeletal muscle , glycogen , glucose uptake , basal (medicine) , biology , islet
Amylin and epinephrine did not significantly affect insulin stimulated, or basal, 3‐ O ‐methylglucose transport in isolated rat soleus muscle, as measured by the release of 3‐ O ‐methylglucose from pre‐loaded tissue. Both amylin and epinephrine inhibited insulin‐stimulated 2‐deoxyglucose uptake (by 25% and 38%, respectively) in soleus muscle from fed rats but not from fasted rats. The latter results are consistent with amylin and epinephrine stimulating glycogenolysis and inhibiting hexokinase activity by intracellular accumulation of glucose 6‐phosphate. We conclude that amylin, like epinephrine, does not specifically inhibit glucose transporters in skeletal muscle.