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Sequence and evolutionary conservation of the murine Gbx‐2 homeobox gene
Author(s) -
Chapman Gavin,
Rathjen Peter D.
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00410-b
Subject(s) - homeobox , homeobox protein nkx 2.5 , emx2 , hnf1b , homeobox a1 , biology , genetics , conserved sequence , gene , sequence (biology) , complementary dna , computational biology , evolutionary biology , peptide sequence , transcription factor
The homeobox gene family is divided into classes based on similarity of sequence across the homeodomain. Representative members of discrete classes are often conserved widely throughout evolution and this can extend to their genomic organisation and biological function. In this paper we report the first complete cDNA sequence of a member of the GBX class of homeobox genes, the murine gene Gbx‐2 . Sequence comparisons indicate that this homeodomain class is highly conserved within vertebrates. The homeodomain differs at only three positions out of 60 and these can be used to subdivide the GBX class homeodomains into 2 sub‐classes.