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Effect of neopterin and 7,8‐dihydroneopterin on tumor necrosis factor‐α induced programmed cell death
Author(s) -
Gabriele BaierBitterlich,
Dietmar Fuchs,
Christian Murr,
Gilbert Reibnegger,
Gabriele Werner-Felmayer,
Roswitha Sgonc,
Günther Böck,
Dierich Mp,
Helmut Wächter
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00403-v
Subject(s) - neopterin , reactive oxygen species , apoptosis , oxidative stress , programmed cell death , chemistry , tumor necrosis factor alpha , necrosis , monocyte , oxygen , cell , microbiology and biotechnology , biochemistry , cancer research , biology , immunology , medicine , organic chemistry
Tumor necrosis factor‐α and the formation of reactive oxygen intermediates are central mediators of apoptosis. Recent data indicated a role of neopterin and 7,8‐dihydroneopterin in oxygen radical mediated processes. We have therefore investigated the effect of neopterin‐derivatives on TNFα induced apoptosis of the monocyte‐like cell line U937. At an elevated concentration 7,8‐dihydroneopterin was found to superinduce TNFα mediated programmed cell death due to the formation of reactive oxygen intermediates. Our results imply that in combination with TNFα high concentrations of 7,8‐dihydroneopterin enhances apoptosis due to oxidative stress on cells.