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Oligomannose‐coated liposomes as an adjuvant for the induction of cell‐mediated immunity
Author(s) -
Sugimoto Masanobu,
Ohishi Kazue,
Fukasawa Masashi,
Shikata Kohdoh,
Kawai Hiromi,
Itakura Hideyo,
Hatanaka Masakazu,
Sakakibara Ryuzo,
Ishiguro Masatsune,
Nakata Munehiro,
Mizuochi Tsuguo
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00279-i
Subject(s) - liposome , immunogenicity , adjuvant , ovalbumin , mannan , chemistry , mannose , immunity , biochemistry , immunology , immune system , biology , polysaccharide
The effect of the coating of ovalbumin‐reconstituted liposomes with various oligosaccharides on their immunogenicity was investigated in mice. The coating of liposomes with oligomannose or yeast mannan drastically enhanced their ability to induce an ovalbumin‐specific delayed‐type footpad swelling response with a peak at 24 to 48 h post‐challenge. Among various oligosaccharides tested, only those with mannose residue at the non‐reducing termini manifested the activity when applied to liposomes. Since such oligosaccharides are ubiquitously found in the body, these results suggested the usefulness of oligomannose‐coated liposomes as a safe adjuvant for the induction of cell‐mediated immunity.