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Hepatocyte growth factor remains as an inactive single chain after partial hepatectomy or unilateral nephrectomy
Author(s) -
Tang Wangxian,
Miyazawa Keiji,
Kitamura Naomi
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00251-4
Subject(s) - hepatocyte growth factor , hepatotoxin , liver regeneration , nephrectomy , hepatectomy , regeneration (biology) , hepatocyte , medicine , kidney , endocrinology , chemistry , biology , surgery , toxicity , microbiology and biotechnology , biochemistry , in vitro , receptor , resection
Hepatocyte growth factor (HGF) is a potent mitogen for hepatocytes and renal tubular epithelial cells. HGF is proteolytically activated in the tissue injured by hepatotoxin or nephrotoxin, suggesting that HGF functions as a crucial growth factor for tissue regeneration following hepatotoxin‐ or nephrotoxin‐induced injury. In this study, we analyzed the molecular form of HGF after partial hepatectomy or after unilateral nephrectomy. The active form of HGF was not detected under our experimental conditions after these operations. Thus, HGF may play little role in liver regeneration after partial hepatectomy and in compensatory renal enlargement after unilateral nephrectomy.