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The arrestin superfamily: cone arrestins are a fourth family
Author(s) -
Craft Cheryl M.,
Whitmore Donald H.
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00213-s
Subject(s) - arrestin , xenopus , biology , homology (biology) , gene , gene duplication , microbiology and biotechnology , complementary dna , gene family , superfamily , genetics , g protein coupled receptor , receptor , genome
Arrestins constitute a superfamily of regulatory proteins that down‐regulate phosphorylated G‐protein membrane receptors, including rod and cone photoreceptors and adrenergic receptors. The potential role of arrestin in color visual processes led us to identify a cDNA encoding a cone‐like arrestin in Xenopus laevis , the principle amphibian biological model system. Alignment of 18 deduced amino acid sequences of all known arrestins from both invertebrate and vertebrate species reveals five arrestin families. Further analysis identifies 7 variable and 4 conservative arrestin structural motifs that may identify potential functional domains. The adaptive evolutionary relationship of Xenopus cone arrestin to the arrestin gene tree suggests high intrafamily homology and early gene duplication events.