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Myogenin binds to and represses c‐ fos promoter
Author(s) -
Trouche Didier,
Masutani Hiroshi,
Groisman Regina,
Robin Philippe,
Lenormand Jean-Luc,
Harel-Bellan Annick
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00140-5
Subject(s) - myogenin , psychological repression , repressor , transcription factor , biology , microbiology and biotechnology , cell growth , transcription (linguistics) , serum response element , gene , serum response factor , gene expression , genetics , linguistics , philosophy
Myogenin (a member of the myogenic basic helixloop‐helix transcription factor family) seems to be the main effector of proliferation repression, a crucial step which precedes muscle cell terminal differentiation during muscle development. Proliferation repression most likely occurs through inhibition of proliferation‐associated genes such as the proto‐oncogene, c‐ fos . Here, we demonstrate that myogenin binds to an E‐box located in the main element of the c‐ fos promoter, the serum response element (SRE). Results from co‐transfection experiments indicate that myogenin acts as a repressor for the SRE. Our data suggest that myogenin could play a role in c‐ fos inhibition at the onset of muscle cell terminal differentiation.