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α ‐Tocopherol mediated peroxidation in the copper (II) and met myoglobininduced oxidation of human low density lipoprotein: The influence of lipid hydroperoxides
Author(s) -
Misato Iwatsuki,
Etsuo Niki,
David A. Stone,
Victor DarleyUsmar
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00122-p
Subject(s) - lipid peroxidation , tocopherol , chemistry , copper , low density lipoprotein , lipoprotein , biochemistry , oxidative phosphorylation , lipid oxidation , vitamin e , medicine , antioxidant , cholesterol , organic chemistry
The principal antioxidant in human LDL, α ‐tocopherol, is converted to the α ‐tocopheroxyl radical after reaction with peroxyl radicals or Cu 2+ , and, if it does not terminate with peroxyl radicals, could initiate lipid peroxidation; a phenomenon called ‘tocopherol mediated peroxidation’. Only in the presence of Cu 2+ and low levels of lipid hydroperoxides was an α ‐tocopherol dependent decrease in the resistance of LDL to oxidation detected. This suggests that tocopherol mediated peroxidation will probably not contribute significantly as a pro‐oxidant process in those individuals most at risk of developing atherosclerosis through an oxidative mechanism.