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Unique molecular properties of superoxide dismutase from teleost fish skin
Author(s) -
Nakano Toshiki,
Sato Minoru,
Takeuchi Masaaki
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00084-m
Subject(s) - superoxide dismutase , fish <actinopterygii> , chemistry , biochemistry , biology , fishery , antioxidant
A unique Cu,Zn‐SOD was found and isolated from plaice Paralichthys olivaceus skin. Surprisingly, the properties of purified fish skin SOD were very different from those of SOD from other sources reported so far. The purified SOD was composed of four same subunits of 16 kDa and the molecular weight of the native SOD was found to be around 65 kDa. The dominant amino acids of the SOD were Ser, Thr, Pro and Glu. Above 70°C, thermostability of the SOD was much lower than that of bovine erythrocyte Cu,Zn‐SOD.