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Modulation of the levels of ouabain‐like compound by central catecholamine neurons in rats
Author(s) -
Yamada Kaoru,
Goto Atsuo,
Omata Masao
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00078-n
Subject(s) - catecholamine , adrenergic neurons , ouabain , endocrinology , medicine , chemistry , adrenergic , norepinephrine , hydroxydopamine , endogeny , central nervous system , ascorbic acid , sympathectomy , dopamine , biology , receptor , dopaminergic , sodium , food science , organic chemistry
Catecholamine regulates the Na + ,K + ‐ATPase activity in the central nervous system and the Na + ,K + ‐ATPase has been shown to have endogenous ligands (ouabain‐like compound; OLC). To examine the relationship between OLC and central adrenergic neurons, we evaluated the effects of central sympathectomies with intracerebroventricular (i.c.v.) injection of 6‐hydroxydopamine (6‐OHDA; 250 μg) on brain and plasma OLC levels and brain catecholamine levels. In centrally sympathectomized rats, hypothalamic OLC content and plasma OLC level were significantly decreased by 90% ( P < 0.01) and 70% ( P < 0.01), respectively, in accordance with reduced brain norepinephrine content compared with control rats pretreated by i.c.v. injection of vehicle (ascorbic acid). On the other hand, peripheral sympathectomy with a similar manner did not affect plasma OLC level at all. These findings suggest that central adrenergic neurons may be involved in the synthesis and/or release of circulating OLC.