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A critical mutation in both WT1 alleles is not sufficient to cause Wilms' tumor
Author(s) -
Kikuchi Haruhito,
Akasaka Yoshikiyo,
Kurosawa Yoshihiro,
Yoneyama Hiroshi,
Kato Shingo,
Hata Jun-ichi
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00071-g
Subject(s) - wilms' tumor , allele , point mutation , germline , mutation , germline mutation , tumor suppressor gene , gene , cancer research , suppressor , biology , genetics , microbiology and biotechnology , carcinogenesis
The WT1 gene is a tumor suppresser gene for Wilms' tumor (WT). Inactivation of both alleles has been proposed as the cause of WT. We encountered a patient with Denys‐Drash syndrome associated with WT whose WT1 gene had a homozygous point mutation not only in WT but also in renal tissue adjacent to the WT and in the germline. These findings indicate that factor(s) other than the loss of WT1 are required for WT to develop.