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The non‐steroidal anti‐inflammatory drug, indomethacin, as an inhibitor of HIV replication
Author(s) -
Bourinbaiar Aldar S.,
Lee-Huang Sylvia
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00057-g
Subject(s) - drug , human immunodeficiency virus (hiv) , pharmacology , replication (statistics) , virology , chemistry , medicine
Indomethacin, a common non‐steroidal anti‐inflammatory drug (NSAID), has been used to treat rheumatoid arthritis. Although indomethacin has also been used as an immunopotentiator and symptomatic NSAID in AIDS, its effect on HIV replication is unknown. MT‐4 lymphocytes were inoculated with HIV in the presence of indomethacin and tested for p24 expression by ELISA. The 50% inhibition (IC 50 ) was 10 μM, corresponding to plasma levels after administration of 50 mg oral indomethacin. The antiviral effect appears to be specific since no toxicity has been observed at the IC 50 dose, and unrelated NSAIDs have not shown the activity at clinical doses. Indomethacin may, thus, represent a new class of anti‐HIV drug.