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Systemic production of foreign peptides on the particle surface of tobacco mosaic virus
Author(s) -
Sugiyama Yoshinori,
Hamamoto Hiroshi,
Takemoto Shizume,
Watanabe Yuichiro,
Okada Yoshimi
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00054-d
Subject(s) - tobacco mosaic virus , virology , hemagglutinin (influenza) , epitope , virus , antiserum , chemistry , biology , antigen , immunology
By using a new tobacco mosaic virus (TMV) vector [Hamamoto, H., et al. (1993) Bio/Technology, 11, 930–932], we have constructed TMV particles which present three different kinds of epitopes, two of them from influenza virus hemagglutinin (HA), and one from human immunodeficiency virus type I (HIV‐I) envelope protein, on the surface of the particles. Each of these TMV particles reacted with each anti‐peptide antiserum. These results suggest that this TMV vector can be used as an antigen presentation system.