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The effect of iron status on glyceraldehyde 3‐phosphate dehydrogenase expression in rat liver
Author(s) -
Quail Elizabeth A.,
Yeoh George C.T.
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00023-3
Subject(s) - glyceraldehyde 3 phosphate dehydrogenase , chemistry , glyceraldehyde , dehydrogenase , biochemistry , phosphate , enzyme
The influence of iron status on glyceraldehyde 3‐phosphate dehydrogenase (GAPDH) gene transcription, mRNA levels and distribution was determined in whole liver samples from adult Wistar rats. While iron loading did not alter GAPDH expression, iron deficiency evoked a 2.3‐fold increase in the steady‐state level of liver GAPDH mRNA, but did not affect gene transcription or intracellular localisation of the message. Therefore, the over‐expression of GAPDH mRNA in iron deficiency is probably due to increased message stability.