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Dual effects of microwaves on single Ca 2+ ‐activated K + channels in cultured kidney cells Vero
Author(s) -
Geletyuk Vitaliy I.,
Kazachenko Vladimir N.,
Chemeris Nicolay K.,
Fesenko Evgeniy E.
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)00002-q
Subject(s) - microwave , biophysics , cooperativity , chemistry , analytical chemistry (journal) , patch clamp , physics , biology , biochemistry , chromatography , receptor , quantum mechanics
Using the patch voltage‐clamp method, possible effects of millimetre microwaves (42.25 GHz) on single Ca 2+ ‐activated K + channels in cultured kidney cells ( Vero ) were investigated. It was found that exposure to the field of non‐thermal power (about 100 μW/cm 2 ) for 20–30 min greatly modifies both the Hill coefficient and an apparent affinity of the channels for Ca i 2+ . The data suggest that the field alters both cooperativity and binding characteristics of the channel activation by internal Ca 2+ . The effects depend on initial sensitivity of the channels to Ca 2+ and the Ca 2+ concentration applied.