Premium
Two hypotheses ‐ one answer
Author(s) -
Soppa Jörg
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)80573-3
Subject(s) - bacteriorhodopsin , shuffling , gene duplication , g protein coupled receptor , biology , sequence homology , gene , genetics , computational biology , homology (biology) , exon , protein family , sequence (biology) , exon shuffling , evolutionary biology , peptide sequence , receptor , tandem exon duplication , computer science , membrane , programming language
The structure of bacteriorhodopsin (BR) of Halobacterium halobium is known. Despite the lack of sequence similarities it is often taken as a model for eukaryotic G‐protein‐coupled receptors (GPCRs). Recently two hypotheses were used to support the homology of BR and GPCRs, namly evolution by exon shuffling and evolution by gene duplication. BR is a member of a family of halobacterial retinal proteins. The sequences of eight members of this family were used to test the two hypotheses. Based on sequence comparison, no indication for an evolutionary linkage between the two protein families could be found.