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Author(s)
Soppa Jörg
Publication year1994
Publication title
febs letters
Resource typeJournals
PublisherWiley-Blackwell
The structure of bacteriorhodopsin (BR) of Halobacterium halobium is known. Despite the lack of sequence similarities it is often taken as a model for eukaryotic G‐protein‐coupled receptors (GPCRs). Recently two hypotheses were used to support the homology of BR and GPCRs, namly evolution by exon shuffling and evolution by gene duplication. BR is a member of a family of halobacterial retinal proteins. The sequences of eight members of this family were used to test the two hypotheses. Based on sequence comparison, no indication for an evolutionary linkage between the two protein families could be found.
Subject(s)bacteriorhodopsin , biology , computational biology , computer science , evolutionary biology , exon , exon shuffling , g protein coupled receptor , gene , gene duplication , genetics , homology (biology) , membrane , peptide sequence , programming language , protein family , receptor , sequence (biology) , sequence homology , shuffling , tandem exon duplication
Language(s)English
SCImago Journal Rank1.593
H-Index257
eISSN1873-3468
pISSN0014-5793
DOI10.1016/0014-5793(94)80573-3
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