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Molecular cloning of the S ‐adenosylmethionine synthetase gene in Drosophila melanogaster
Author(s) -
Larsson Jan,
Rasmuson-Lestander Åsa
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)80526-1
Subject(s) - drosophila melanogaster , gene , cloning (programming) , genetics , molecular cloning , biology , drosophila (subgenus) , gene expression , computer science , programming language
We have isolated and sequenced cDNA clones encoding the Drosophila melanogaster S ‐adenosylmethionine synthetase. The deduced amino acid sequence contains 405 amino acid residues and shows high homology to rat, yeast, Arabidopsis and Escherichia coli counterparts. The gene is transcribed throughout Drosophila development but its main activity is seen in adult males and females. The highest transcription activity is seen in female ovaries. The transcript has an unusually long 5′‐untranslated region, which might be of importance for translational regulation.