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Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain
Author(s) -
Ishiguro Koichi,
Kobayashi Shunsuke,
Onion Akira,
Takamatsu Masako,
Yonekura Sayuri,
Anzai Kaijiro,
Imahori Kazutomo,
Uchida Tsuneko
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)80501-6
Subject(s) - cyclin dependent kinase 5 , cyclin dependent kinase complex , protein subunit , cyclin dependent kinase 9 , cyclin dependent kinase 1 , activator (genetics) , cyclin dependent kinase 2 , protein kinase a , microbiology and biotechnology , mitogen activated protein kinase kinase , biology , kinase , cyclin dependent kinase 4 , phosphopeptide , biochemistry , cell cycle , cell , gene
Tau protein kinase II (TPKII) was reported previously to be composed of a neuron‐rich cdc2‐related kinase (PSSALRE/cdk5) and 23 kDa subunit. Here we show that the 23 kDa subunit is a putative activator for the kinase activity. Amino acid sequence analysis revealed that the protein was novel and included a partial similarity of amino acids to a cyclin box important for the interaction with cdc2‐related kinase. These results suggest that the 23 kDa subunit, but not cyclin, activates cdk5 in neuronal cells, which no longer exhibit cell cycling but are terminally differentiated cells.