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β‐Cyclodextrin interacts with the Alzheimer amyloid β‐A4 peptide
Author(s) -
Camilleri Patrick,
Haskins Neville J.,
Hewlett David R.
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)80467-2
Subject(s) - peptide , chemistry , cyclodextrin , mass spectrometry , oligosaccharide , amyloid (mycology) , electrospray , combinatorial chemistry , stereochemistry , biochemistry , biophysics , chromatography , inorganic chemistry , biology
Electrospray ionisation mass spectrometry has been used to show that the synthetic 40 amino acid β‐amyloid peptide (β1‐40) interacts with the cyclic oligosaccharide β‐cyclodextrin. This interaction, presumably with the hydrophobic aromatic moieties on the peptide, has been shown to diminish substantially the neurotoxic effects of β1‐40 in a cell line.