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YGE1 is a yeast homologue of Escherichia coli grpE and is required for maintenance of mitochondrial functions
Author(s) -
Ikeda Eri,
Yoshida Satoshi,
Mitsuzawa Hiroshi,
Uno Isao,
Toh-e Akio
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)80428-1
Subject(s) - escherichia coli , chaperone (clinical) , yeast , biology , mitochondrion , heat shock protein , gene product , gene , escherichia coli proteins , saccharomyces cerevisiae , biochemistry , microbiology and biotechnology , gene expression , medicine , pathology
The grpE gene is a heat shock gene of Escherichia coli whose product functions as a chaperone to (re)fold proteins. We found a yeast homologue of grpE and designated it YGE1. YGE1 can replace grpE in E coli , indicating that YGE1 is a functional homologue of grpE . Deletion of YGE1 is lethal. During depletion of the Ygel product, mitochondria are sequestered in mother cells thereby accumulating cells without mitochondria, suggesting that Ygel protein plays a pivotal role in maintaining mitochondrial functions.