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Vitamin K‐antagonistic effect of plastoquinone and ubiquinone derivatives in vitro
Author(s) -
Saupe Jörg,
Ronden Jacintha E.,
Soute Berry A.M.,
Vermeer Cees
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)80352-8
Subject(s) - plastoquinone , chemistry , biochemistry , reductase , quinone , in vitro , enzyme , pyruvate carboxylase , stereochemistry , chloroplast , thylakoid , gene
Decyl‐ubiquinone and decyl‐plastoquinone were used as model compounds to test the potential effect of quinone derivatives on two enzymes of the vitamin K cycle in vitro. Substantial inhibition of γ‐glutamate carboxylase was found, whereas vitamin K‐epoxide reductase was inhibited to a much lesser extent. The inhibitory effect of both decylquinones was eliminated in a time‐dependent way by solubilized microsomes, but not by purified carboxylase. Since a wide variety of prenylquinones occur as micronutrients, these results are of potential relevance for the effects of natural quinones in the human diet.