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Progesterone increases the production of tissue inhibitor of metalloproteinases‐2 in rabbit uterine cervical fibroblasts
Author(s) -
Imada Keisuke,
Ito Akira,
Itoh Yoshifumi,
Nagase Hideaki,
Mori Yo
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)80250-5
Subject(s) - matrix metalloproteinase , connective tissue , chemistry , endocrinology , medicine , andrology , tissue inhibitor of metalloproteinase , biology , pathology , biochemistry
Rabbit uterine cervical fibroblasts in culture produces tissue inhibitor of metalloproteinases (TIMP)‐l and TIMP‐2. When cells were treated with physiological concentrations of progesterone, the production of two TIMPs increased, and essentially all TIMP‐2 was found to be complexed with promatrix metalloproteinase 2 (proMMP‐2)/progelatinase A. Progesterone did not modulate the production of proMMP‐2 and resulted in the increased total amount of proMMP‐2‐TIMP‐2 complex. These observations provide the first evidence that progesterone participates in maintaining the homeostasis of connective tissue matrix in uterine cervix by augmenting both TIMP‐1 and TIMP‐2 production along with the known suppressive effects on the proMMP‐1 and proMMP‐3 production.