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Phosphate‐activated glutaminase expression during tumor development
Author(s) -
Aledo Juan C.,
Segura Juan A.,
Medina Miguel A.,
Alonso Francisco J.,
de Castro Ignacio Núñez,
Marquez Javier
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)80236-x
Subject(s) - phosphate , glutaminase , chemistry , biochemistry , microbiology and biotechnology , glutamine , biology , amino acid
Changes in phosphate‐activated glutaminase activities determined in intact cells and isolated mitochondria have been followed during mouse Ehrlich ascites carcinoma development. Glutaminase activities parallel the levels of poly(A) + RNAs encoding for the mitochondrial phosphate activated glutaminase. During the exponential growth phase, maximum activity was observed and the relative abundance of glutaminase mRNA significantly increased with regard to the stationary growth phase. The presented results show that tumor phosphate‐activated glutaminase is subject to long‐term regulation by differential gene expression.