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Anaesthetic phencyclidine, blocker of the ATP‐sensitive potassium channels
Author(s) -
Kokoz Yuri M.,
Alekseev Alexey E.,
Povzun Alexander A.,
Korystova Antonina F.,
Peres-Saad Hector
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)80208-4
Subject(s) - phencyclidine , potassium channel , chemistry , biophysics , auricle , patch clamp , sucrose gap , potassium channel blocker , potassium , electrophysiology , pharmacology , anatomy , medicine , membrane potential , biology , biochemistry , receptor , nmda receptor , organic chemistry
The double sucrose gap and patch‐clamp studies revealed that phencyclidine blocked the ATP‐sensitive K + channel in isolated cardiac cells (half‐maximal inhibition at ≈20 μM; Hill coefficient ≈1). 10μM phencyclidine increased the inward Ca 2+ current and blocked the outward K + current in the frog auricle trabeculae. The phencyclidine effects on the frog auricle trabeculae and the isolated cardiac cells proved to be quite reversible.