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Genes for members of the GATA‐binding protein family (GATA‐GT1 and GATA‐GT2) together with H + /K + ‐ATPase are specifically transcribed in gastric parietal cells
Author(s) -
Mushiake Sotaro,
Etani Yuri,
Shimada Shoichi,
Tohyama Masaya,
Hasebe Masahisa,
Futai Masamitsu,
Maeda Masatomo
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)80184-3
Subject(s) - protein subunit , parietal cell , microbiology and biotechnology , gene , biology , atpase , dna , chemistry , gastric mucosa , biochemistry , enzyme , stomach
mRNAs for novel DNA‐binding proteins (GATA‐GT1 and GATA‐GT2) recognizing the (G/C)PuPu(G/C)NGAT(A/T)PuPy sequence and H + /K + ‐ATPase (proton pump) α subunit were detected in parietal cells of the rat gastric body mucosa by in situ hybridization. These results suggest that GATA‐GT1 and GATA‐GT2 together with H + K + ‐ATPase are transcribed specifically in gastric parietal cells and that the two DNA‐binding proteins may have important roles in cell specific gene regulation. Furthermore, we could detect parietal cells in different states of gene expression.