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Molecular mechanisms of tumor necrosis factor‐induced cytotoxicity
Author(s) -
Beyaert Rudi,
Fiers Walter
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)80163-0
Subject(s) - cytotoxicity , tumor necrosis factor alpha , cytokine , cytotoxic t cell , microbiology and biotechnology , biology , receptor , cancer research , signal transduction , chemistry , immunology , in vitro , biochemistry
Although TNF plays an important role in several physiological and pathological conditions, the hallmark of this important cytokine has been its selective cytotoxic activity on tumor cells. Since its cloning in 1984, understanding of how TNF selectively kills tumor cells has been the subject of research in many laboratories. Here we review TNF‐induced post‐receptor signaling mechanisms which seem to be involved in the pathway to cytotoxicity.