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Squamous cell carcinoma antigen is a potent inhibitor of cysteine proteinase cathepsin L
Author(s) -
Takeda Atsushi,
Yamamoto Takako,
Nakamura Yoshiko,
Takahashi Tadahito,
Hibino Toshihiko
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)01456-b
Subject(s) - cysteine , cysteine proteinase inhibitors , cathepsin , cathepsin b , cathepsin l , proteinase inhibitor , antigen , cancer research , chemistry , basal cell , carcinoma , microbiology and biotechnology , biochemistry , enzyme , biology , medicine , immunology , apoptosis , programmed cell death , caspase
A squamous cell carcinoma antigen (SSCA), which is a member of the serpin family of proteinase inhibitors, was purified from sera of cancer patients. It did not inhibit serine proteinases. However, it non‐competitively inhibited human cathepsin L with a K i of 0.064 nM, but not cathepsins B and H among cysteine proteinases. These results indicated that SCCA is a non‐functional serpin that inhibits cathepsin L in cancer cells.