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Possible involvement of the transcription factor ISGF3γ in virus‐induced expression of the IFN‐β gene
Author(s) -
Kawakami Takatoshi,
Matsumoto Masahito,
Sato Mitsuharu,
Harada Hisashi,
Taniguchi Tadatsugu,
Kitagawa Motoo
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)01426-2
Subject(s) - transcription factor , gene expression , gene , chemistry , transcription (linguistics) , microbiology and biotechnology , biology , virology , biochemistry , philosophy , linguistics
Two virus‐inducible transcription factors, IRF‐1 and IRF‐2 have been identified as an activator and a repressor, respectively, of the type I interferon (IFN) genes. Recent studies with mice carrying null mutations for the IRF‐1 or IRF‐2 alleles have revealed the existence of IRF‐1‐dependent and ‐independent pathways mediating IFN‐β gene induction. Here we report that the expression of an IRF family member ISGF3γ is induced upon viral infection in IRF‐1‐/‐, IRF‐2‐/‐ embryonic fibroblasts. Furthermore, ISGF3γ can bind to a virus‐inducible promoter element in the IFN‐β gene. These results suggest that ISGF3γ or complex containing ISGF3γ is involved in the IRF‐1‐independent pathway mediating IFN‐β gene regulation.