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The rsp5‐domain is shared by proteins of diverse functions
Author(s) -
Hofmann Kay,
Bucher Philipp
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)01415-w
Subject(s) - c2 domain , biology , protein domain , hamp domain , microbiology and biotechnology , gatad2b , grb2 , computational biology , gene , protein–protein interaction , cytoplasm , genetics , signal transducing adaptor protein , hspa9 , peptide sequence , membrane
A novel, unusually small, and highly conserved domain of modular intracellular proteins is described. The domain was first recognized as three repeats in the yeast rsp5 gene product and named thereafter. The rsp5 protein is thought to interact with nuclear proteins but also contains a C2 domain typical for cytoplasmic proteins. Further analyses revealed several additional occurrences of this domain in diverse protein classes, including cytoplasmic signal transduction proteins, gene products interacting with the transcription machinery, structural proteins like dystrophin, and a putative RNA helicase.