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Curcacycline A — a novel cyclic octapeptide isolated from the latex of Jatropha curcas L
Author(s) -
van den Berg A.J.J.,
Horsten S.F.A.J.,
Kettenes-van den Bosch J.J.,
Kroes B.H.,
Beukelman C.J.,
Leeflang B.R.,
Labadie R.P.
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)01405-p
Subject(s) - jatropha curcas , euphorbiaceae , valine , glycine , stereochemistry , threonine , traditional medicine , leucine , chemistry , botany , biochemistry , amino acid , biology , serine , medicine , enzyme
From the latex of Jatropha curcas L. (Euphorbiaceae) a novel cyclic octapeptide was isolated, which we named curcacycline A. The compound was found to contain one threonine, one valine, two glycine, and four leucine residues. By two‐dimensional 1 H‐NMR spectroscopy (HOHAHA and ROESY), its sequence was determined to be Gly 1 ‐Leu 2 ‐Leu 3 ‐Gly 4 ‐Thr 5 ‐Val 6 ‐Leu 7 Leu 8 ‐Gly 1 . Curcacycline A displays a moderate inhibition of (i) classical pathway activity of human complement and (ii) proliferation of human T‐cells.