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Human A‐ myb gene encodes a transcriptional activator containing the negative regulatory domains
Author(s) -
Takahashi Tomomi,
Nakagoshi Hideki,
Sarai Akinori,
Nomura Nobuo,
Yamamoto Tadashi,
Ishii Shunsuke
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)01402-m
Subject(s) - myb , activator (genetics) , biology , transcription factor , gene , transcription (linguistics) , regulation of gene expression , microbiology and biotechnology , genetics , linguistics , philosophy
The myb gene family has three members, c‐ myb , A‐ myb , and B‐ myb . A‐myb mRNA is mainly expressed in testis and peripheral blood leukocytes. A‐Myb can activate transcription from the promoter containing Myb‐binding sites in all cells examined. In addition to the two domains (a DNA‐binding domain and a transcriptional activation domain), two negative regulatory domains have been identified in A‐Myb. These results indicate that A‐Myb functions as a transcriptional activator mainly in testis and peripheral blood cells, and the regulatory mechanism of A‐Myb activity is similar to that of c‐Myb.