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Temperature‐induced micellar‐lamellar transformation in binary mixtures of saturated phosphatidylcholines with sodium cholate
Author(s) -
Polozova Alla I.,
Dubachev Gennady E.,
Simonova Tatya.,
Barsukov Leonid I.
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)01378-e
Subject(s) - vesicle , sodium cholate , micelle , differential scanning calorimetry , chemistry , lamellar structure , turbidimetry , amphiphile , crystallography , membrane , chromatography , organic chemistry , thermodynamics , aqueous solution , copolymer , biochemistry , polymer , physics
The transition states of binary mixtures of dipalmitoyl‐ and dimyristoylphosphatidylcholines with sodium cholate at the reversible temperature‐induced micellar‐lamellar transformation were characterized by turbidimetry, electron microscopy, 31 P NMR and differential scanning calorimetry. This transformation is triggered by the phospholipidacyl chain melting, and appears to include two structural pathways: (i) from discoidal mixed micelles to network‐like structures composed of long interlaced rod‐like micelles, then to multilayer membrane structures, and finally to multilamellar vesicles; and (ii) from discoidal micelles to membrane fragments and finally to unilamellar vesicles.