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Pro‐oxidant effects of 7‐hydroperoxycholest‐5‐en‐3β‐ol on the copper‐initiated oxidation of low density lipoprotein
Author(s) -
Blache D.,
Rodriguez C.,
Davig J.
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)01348-5
Subject(s) - chemistry , low density lipoprotein , cholesterol , alcohol , lipoprotein , copper , lipid oxidation , oxidative phosphorylation , ldl cholesterol , biochemistry , medicine , organic chemistry , antioxidant
In low density lipoproteins (LDL) supplemented with aged cholesterol and oxidized in the presence of Cu 2+ , an increase of the lipid oxidation parameters was observed compared with pure cholesterol‐enriched LDL. A compound, identified as 7‐hydroperoxycholesterol (7HPC), isolated from aged cholesterol and added to LDL, reproduced the above effects. The results indicate that the pro‐oxidant effect of 7HPC is dependent on the hydroperoxy group since the corresponding alcohol derivative, 7α‐hydroxycholesterol, had no such effect. These data suggest that among the LDL‐associated lipid peroxides, cholesterol peroxides may have important implications in the susceptibility of this lipoprotein to oxidation.