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Differential penetration of fatty acyl‐coenzyme A and fatty acylcarnitines into phospholipid monolayers
Author(s) -
Asun Requero M.,
González Martín,
Goñi Félix M.,
Alonso Alicia,
Fidelio Gerardo
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)01326-v
Subject(s) - phospholipid , chemistry , monolayer , biochemistry , coenzyme a , penetration (warfare) , cofactor , membrane , enzyme , operations research , reductase , engineering
The ability of fatty acyl‐CoA's and fatty acylcarnitines to penetrate phospholipid monolayers was comparatively studied, in view of the important role of both kinds of derivatives in fatty acid transport across mitochondrial membranes. The interaction occurs predominantly through hydrophobic forces. Acylcarnitines penetrate phospholipid monolayers more strongly than acyl‐CoAs; in addition the former show a positive cooperativity when they bind to the interface. These properties would facilitate membrane transfer of fatty acylcarnitines over that of their CoA homologues.